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Ro 16:1-2 commends Phoebe to the Romans. Phoebe, from nearby Cenchrea, is going to Rome. Paul takes this opportunity to send this epistle with her.
In 16:3-16 Paul sends greetings to certain people who probably had been with him in the East and later moved to Rome.
Toward the end of the letter, Paul probably took the pen from Tertius (v.22), his secretary, and wrote the words in 16:17-20. He cautions the Romans about heretics. One way to resist heretics is to understand and hold fast to the accepted doctrine. Another important step is to stay away from them, giving them no chance to spread their heresy (v.17). In this conflict with Satan, the victory will come from two sides: the one, divine (God . . . will . . . crush) and the other, human (under your feet, v.20). God gives strength, but we have to appropriate and use it. Paul concludes his own writing with a benediction (v.20).
In 16:21-24 those who are with Paul send greetings to the Roman Christians.
The entire epistle ends with the benediction and doxology of 16:25-27. Like the opening section of the epistle, this closing benediction and doxology include a statement about the Gospel.