ESV Reformation Study Bible – 1 Tim 4:1
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1 Tim 4:1

4:1 the Spirit expressly says. Presumably a specific revelation the Holy Spirit granted to someone, perhaps Paul himself (Acts 20:22–31; cf. 21:11).

in later times. This is not a period just prior to the Second Coming of Christ. Rather, in keeping with the overall New Testament perspective, it is the era inaugurated by Christ’s First Advent and completed at His second (Acts 2:17; Heb. 1:2; 1 Pet. 1:20; 1 John 2:18; cf. 2 Tim. 3:1).

some will . . . demons. A reference to the false teachers, who have arisen within the church.